Conference Proceedings
The thalamocortical circuit and the generation of epileptic spikes in rat models of focal epilepsy.
DR Freestone, DB Grayden, A Lai, TS Nelson, A Halliday, AN Burkitt, MJ Cook
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference | IEEE | Published : 2009
Abstract
We investigate thalamocortical interactions in the tetanus toxin and the cortical stimulation rat models of epilepsy. Using local field potential recordings from the cortex and the thalamus of the rat, the nonlinear regression index is calculated to create the direction index in order to study neurodynamics during seizures. Coarse time-scale analysis reveals that the cortex drives the thalamus for the majority of the time during seizures. However, fine time-scale analysis provides evidence that epileptic spikes are driven from the thalamus. This new result has implications for understanding, diagnosing and using electrical stimulation to treat epileptic seizures.
Grants
Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the Australian Research Council Linkage Grant LP0560684. The Bionic Ear Institute acknowledges the support it receives from the Victorian Government through its Operational Infrastructure Support Program